What naloxone doses should be used in adults to urgently reverse the effects of opioids?

The opioid antagonist, naloxone, is a highly effective antidote the use of which is potentially life-saving. The drug has a role in a wide range…

Which opioids can be used in renal impairment?

Opioids are used in a wide variety of clinical settings and are well established for the treatment of both acute and chronic pain. Renal impairment…

Espranor (buprenorphine oral lyophilisate) 2mg and 8mg

An overview of the considerations for use of Espranor (buprenorphine oral lyophilisate) 2mg and 8mg for opioid substitution therapy use in community settings and secure environments.

How can you minimise the risks of medication errors with buprenorphine patches?

15/4/2019 –  an update of this document has been published below, the main amendment is a strengthening of the advice on prescribing by brand name. …

What are the equivalent doses of oral morphine to other oral opioids when used as analgesics in adult palliative care?

Morphine is generally the strong opioid of choice for treating moderate to severe cancer pain and a common question is how to convert a dose…

Safety in Lactation: Opioid analgesics

The evidence relating to the safe use of opioid analgesics in breastfeeding mothers is very variable between individual drugs. This group of drugs presents a…

Safety in Lactation: Opioid dependence

An assessment of the risks associated with breastfeeding by an opioid-dependent mother, in terms of sustaining successful breastfeeding and possible exposure of the infant to…