Administration information for AstraZeneca COVID-19 Vaccine

Anna Bischler, Lead Medicines Information Pharmacist, Midlands and East Medicines Advice Service (East Anglia site)Published

Information on batch specific dosing and withdrawing an additional dose from an individual vaccine vial is given.

Batch specific doses

It is not necessary for the same patient to receive both doses of vaccine from the same batch.

The conditions for authorisation state that in light of the batch specific-nature of this approval, and the high demand for this product, providers administering this vaccine should ensure that they have provision for two doses for each patient treated. This advice is not related to batch variation but rather to ensure that there are two doses of the same product available for each vaccinated individual.

See further information if the same brand of vaccine is unavailable for the second dose

Withdrawing a 9th or 11th dose from a vial

The Patient Group Direction (PGD) and the National Protocol allows for the withdrawal of an additional 9th or 11th dose from a vaccine vial (depending on whether an 8 dose or 10 dose vial is received). The PGD and MHRA Information for Healthcare Professionals outlines that each vial contains at least the number of doses stated. When low dead volume syringes and/or needles are used, the amount remaining in the vial may be sufficient for an additional dose. Care should be taken to ensure a full 0.5ml dose is administered. Where a full 0.5ml dose cannot be extracted, the remaining volume should be discarded.