Cannabidiol oil – potential adverse effects and drug interactions

  • Due to an increasing popularity of self-administration of over-the-counter bought CBD, doctors and pharmacists should be aware of its potential adverse effects and interactions.
  • The most common adverse effects found in studies were somnolence, decreased appetite, vomiting, diarrhoea and elevated liver enzymes.
  • Moderate to severe impairment of kidney or liver function may theoretically reduce the clearance and/or excretion of CBD.
  • The data available suggests that CBD interacts with cytochrome p450 enzymes consequently, caution is recommended when CBD is co-administered with medications that are metabolised by this pathway.
  • Readers should consult the UKMi Q&A Cannabis based medicinal products potential drug interactions for further information on potential drug interactions.
  • Information regarding CBD safety is limited to few human studies and information should be interpreted cautiously. Further studies are needed to evaluate the full safety profile.
CannabidiolComplementary and alternative therapiesDronabinol + CannabidiolDrug interactionsMedicines Safety