Comparison of products used in Hereditary Angioedema in the absence of Berinert

· London Medicines Information Service, London North West University Healthcare NHS Trust

This table provides a summary of clinical factors to consider when using alternative complement regulatory proteins to Berinert (C1-esterase inhibitor) .  Supplies of Berinert are expected to go out of stock and patients may need to be treated with Cinryze (C1-esterase inhibitor) , Firazyr (Icatibant) , Takhzyro (Lanadelumab) or Ruconest (Conestat alfa).

Allergy and immunologyC1-esterase inhibitorConestat alfaIcatibantNewsShortages and discontinuationsShortages, Discontinuations and Patent Expiries