Contraindications and cautions summary for AstraZeneca COVID-19 Vaccine

Christine Randall, Assistant Director, Lead pharmacist for Dental Medicines Information and Pharmacovigilance, North West Medicines Information CentrePublished

Specific information for AstraZeneca and signposting to general guidance on contraindications and cautions information common to all COVID-19 vaccines

Contraindications to the vaccine

Manufacturer’s information

The manufacturer’s information for healthcare professionals states hypersensitivity to the active substance or to any of the excipients as a contraindication for use.  Excipients are listed in section 6.1 of the manufacturer’s information.

Cautions with concomitant conditions or medicines

Advice on use may be specific to this vaccine or common across all vaccines. Our articles covering topics in this area relevant to AstraZeneca COVID-19 Vaccine are listed and summarised below by theme.


Advising individuals with allergies on their suitability for AstraZeneca COVID-19 Vaccine

8 January 2021Advice on whether people with a previous allergic reaction can have the AstraZeneca COVID-19 vaccine.

Advising individuals with religious or other dietary practices and beliefs on their suitability for the AstraZeneca COVID-19 Vaccine

7 January 2021Advice on whether people with religious or other dietary practices can receive the AstraZeneca COVID-19 Vaccine.

Anticoagulant use and bleeding disorders

Using COVID-19 vaccines in patients with anticoagulation and bleeding disorders

7 January 2021Information on use of the vaccine in patients who are receiving anticoagulants or have a bleeding disorder is given below.

Infection and febrile illness

Using COVID-19 vaccines in individuals with acute severe febrile illness

8 January 2021Advice on using COVID-19 vaccines in individuals with acute severe febrile illness

Vaccinating individuals with COVID-19 or with a history of COVID-19

31 December 2020Certain groups can be vaccinated where they have already had COVID-19. In some circumstances these individuals may required a COVD-19 test.

Immunosuppressive medicines

Using COVID-19 vaccines in patient taking immunosuppressive medicines

22 January 2021National advice and considerations on the use of this vaccine in patients taking immunosuppressive medicines

Surgery - recent or imminent

Using COVID-19 Vaccines in people with recent or imminent elective surgery

24 December 2020Information to support decision making around timing of COVID-19 vaccine administration in relation to surgery