Contraindications and cautions summary for Pfizer-BioNTech COVID-19 Vaccine

Helen Davis, UKMi, Director, North West Medicines Information CentrePublished Last updated See all updates

Specific information for Pfizer-BioNTech and signposting to general guidance on contraindications and cautions information common to all COVID-19 vaccines

Contraindications to the vaccine

Manufacturer’s information

The manufacturer’s information for healthcare professionals states hypersensitivity to the active substance or to any of the excipients as a contraindication for use.  Excipients are listed in section 6.1 of the manufacturer’s information.

MHRA advice

Previously, the MHRA advised that people who had a history of anaphylaxis to vaccines, drugs or food should not receive the Pfizer COVID-19 vaccination.  However, this advice changed on 31st December. Such individuals can now have the vaccine, unless they are hypersensitive to vaccine itself or any of its ingredients, as outlined in the manufacturer’s information. A summary of the reasons why the MHRA advice changed is available.

Cautions with concomitant conditions or medicines

Advice may be specific to this vaccine or common across all vaccines. Our articles covering topics in this area relevant to Pfizer-BioNTech COVID-19 Vaccine are listed and summarised below by theme.

Advising individuals with allergies on their suitability for Pfizer-BioNTech COVID-19 Vaccine

7 January 2021Advice on whether people with a previous allergic reaction can have the Pfizer-BioNTech COVID-19 vaccine.

Excipients information for Pfizer-BioNTech COVID-19 Vaccine

15 December 2020This page summarises and signposts to publicly available information that we’re aware of from professional and government bodies relating to the Pfizer-BioNTech

Change history

  1. Link to document outlining reasons for MHRA change in advice relating to contraindications to the vaccine.