Dosing information for COVID-19 booster vaccination

Anna Bischler, Lead Medicines Information Pharmacist, Midlands and East Medicines Advice Service (East site)Published

Dosing information for COVID-19 booster vaccination; reinforcing immunisation.

Dose scheduling

Public Health England’s Immunisation Against Infectious Disease (The Green book) states that the Joint Committee for Vaccines and Immunisation (JCVI) recommends that adults who received a primary course in Phase 1 of the COVID-19 vaccination programme (priority groups 1-9) should be offered a COVID-19 booster vaccine.

This includes;

  • those living in residential care homes for older adults,
  • all adults aged 50 years or over,
  • frontline health and social care workers,
  • all those aged 16 to 49 years with underlying health conditions that put them at higher risk of severe COVID-19,
  • adult carers and those experiencing homelessness,
  • adult household contacts of immunosuppressed individuals

The JCVI recommends that the reinforcing dose should be offered no earlier than six months after completion of the primary vaccine course.

Vaccine choice

Public Health England’s Immunisation Against Infectious Disease (The Green book) states that the Joint Committee for Vaccines and Immunisation (JCVI) recommends which vaccine should be given as first line

Pfizer-BioNTech

JCVI recommends the Pfizer-BioNTech vaccine for the booster dose irrespective of the vaccine used for the primary course.

Moderna

JCVI states that as an alternative, individuals may be offered a half dose of the Moderna COVID-19 vaccine.

AstraZeneca

JCVI states that where mRNA vaccines are not suitable, vaccination with the AstraZeneca vaccine may be considered in those who were primed with the same vaccine.

The Patient Group Directions (PGDs) and National Protocols for the Pfizer-BioNTech vaccine may be used to administer the booster dose to those individuals eligible for a booster dose as part of the national COVID-19 vaccination programme.

Information on primary vaccination

Dosing information COVID-19 primary vaccination

Dose scheduling, actions when the intervals are longer than or less than recommended, and use of alternative brands for second doses

Use in conjunction with other material

The legal mechanisms available for giving COVID-19 vaccines and their application

A summary of the different legal mechanisms available, a priority order for the options, and advice on their application to different professional groups.