Fentanyl citrate: syringe compatibility information for use during COVID-19

John Minshull, Deputy Director, London Medicines Information Service, Specialist Pharmacy ServicePublished

During COVID-19 mixing drugs in syringe may be more necessary than normal.  For our background page on syringe compatibility during COVID-19 go here.

Fentanyl citrate is a solution for injection with an acid to neutral pH.

This page gives specific information on compatibility of fentanyl citrate when combined with other medicines in a syringe.  Use this information in conjunction with the detailed information on fentanyl citrate in the national injectable medicines guide.

Known compatibility information for fentanyl citrate

  • Compatible with the Diprivan brand of propofol 1% for up to 90 minutes, at a concentration of up to 2micrograms/mL of fentanyl citrate and up to 9.5mg/mL of propofol
  • Compatible with the Fresenius Kabi brand of propofol 1% and propofol 2% for up to 12 hours, at a conentration of up to 50micrograms/mL of fentanyl citrate and up to 20mg/mL of propofol
  • Compatible with midazolam hydrochloride for up to 24 hours, at a concentration of up to 30micrograms/mL of fentanyl citrate and up to 2.5mg/mL of midazolam hydrochloride

Our advice is constantly reviewed as the pandemic situation evolves; if you spot anything that’s wrong report a concern to us.