Fluorescein products: information for supporting intrathecal risk assessment

John Minshull, Deputy Director, London Medicines Information Service, Specialist Pharmacy ServicePublished

Fluorescein products vary in their licensed status and other characteristics which affects their suitability for intrathecal administration

Licensed for intrathecal use

Products licensed for intrathecal use are the first line option and should be used wherever suitable.

There are currently no known fluorescein products licensed for intrathecal administration.

Not licensed for intrathecal use, limited information available

Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.

Alcon Eye Care (Anantera®)

Strength

100mg/mL in 5mL vial

Excipients

Sodium hydroxide (for pH adjustment), hydrochloric acid (for pH adjustment), water for injection

Osmolarity

572 – 858 mOsmol/Kg

pH

8.0 – 9.8

Endotoxin content

≤ 0.1 EU/mg

SERB

Strength

100mg/mL in 5mL vial

Excipients

Sodium hydroxide (for pH adjustment), water for injection

Osmolarity

798 mOsmol/L

pH

8.0 – 9.0

Endotoxin content

No information

No information available

Products with very little or no information are rarely used for intrathecal administration.

There are currently no known additional fluorescein products.

All our intrathecal product resources

Understand what to consider when giving medicines via the intrathecal route and use our material to help inform your risk assessment

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