This Medicines Q&A evaluates the published information available on the safety of the treatment options for nausea and vomiting in pregnancy.  It includes information on the efficacy and safety of antihistamines (promethazine, cyclizine, prochlorperazine), domperidone, metoclopramide, and Xonvea® (a combination of doxylamine and pyridoxine [vitamin B6]) for nausea and vomiting in pregnancy. The most recent update reflects the most up-to-date evidence and guidance concerning the safety of ondansetron use in pregnancy.