Hypersalivation – what are the treatment alternatives to glycopyrronium and hyoscine?

Samantha Owen, Principal Pharmacist Critical Evaluation and UKMi Medicines Q&A Lead, Southampton Medicines Advice Service, University Hospital of Southampton NHS Foundation TrustSource Southampton Medicines Advice Service, UKMiPublished

This Medicines Q&A outlines possible alternatives to hyoscine hydrobromide and glycopyrronium in the treatment of non drug-induced hypersalivation, e.g. botulinum toxin, amitriptyline, atropine (eye drops administered sublingually), benzatropine (not available in the UK), trihexyphenidyl/benzhexol, and ipratropium bromide (nasal spray administered sublingually).

Update November 2020: this Q&A is in the process of being fully reviewed and updated. In the interim, please use with caution and do not rely on the current document as a sole source of information.