Intrathecal administration of etoposide: a review of current literature and expert opinion

In order to determine the safety of administration of formulations of etoposide via intrathecal routes an attempt was made to distil the relevant detail from personal communications (representing expert clinical opinion) and a thorough literature search (Embase and Medline) reviewing all studies or case reports in which etoposide had been administered into the cerebrospinal fluid (including intracerebral, intracerebroventricular, intraspinal, intrathecal and intratumoral administration). Where possible the product, excipients, and administration technique utilised, as well as any safety concerns raised, were extracted from the references.

Acute CareEtoposideMedicines SafetyNewsParenteral Administration