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Medicines interactions with nirmatrelvir and ritonavir (Paxlovid®)

Helen Davis, Director, North West Medicines Information CentrePublished Last updated See all updates
Topics: Oral antivirals

Guidance on interacting drugs to be used alongside the NHSE/I commissioning policy for Paxlovid®, containing PF-07321332 (nirmatrelvir) and ritonavir.

Using our guidance

You can use our guidance in the attachment below together with the latest commissioning policies for hospitalised and non-hospitalised patients. Together these resources will help teams use PF-07321332 (nirmatrelvir) plus ritonavir (Paxlovid) safely with potentially interacting medicines.

This document may differ in detail compared to that appearing in the commissioning policies. There is no single comprehensive resource listing potential medicines interactions and data is constantly  emerging.

Prescribers need to take appropriate steps to assure themselves of the suitability of  PF-07321332 (nirmatrelvir) plus ritonavir (Paxlovid) in each individual patient.

SPS Paxlovid Interactions document

Change history

  1. Minor typographical errors amended
  1. Updated content aligned with commissioning policy
  1. Published