During COVID-19 mixing drugs in a syringe may be more necessary than normal.  For our background page on syringe compatibility during COVID-19 go here.

Midazolam hydrochloride is a solution for injection with an acid pH.

This page gives specific information on compatibility of midazolam hydrochloride when combined with other medicines in a syringe.  Use this information in conjunction with the detailed information on midazolam hydrochloride in the national injectable medicines guide.

Known compatibility information for midazolam hydrochloride

• Is compatible with alfentanil hydrochloride for up to 24 hours, at a concentration of midazolam hydrochloride up to 0.2mg/mL and at a concentration of alfentanil hydrochloride up to 0.5mg/mL, with sodium chloride 0.9% used as a diluent
• Is compatible with alfentanil hydrochloride for up to 12 hours, at a concentration of midazolam hydrochloride up to 1.1mg/mL and a concentration of alfentanil hydrochloride up to 2.7mg/mL, with sodium chloride 0.9% used as a diluent
• Is compatible with fentanyl citrate for up to 24 hours, at a concentration of midazolam hydrochloride up to 2.5mg/mL and a concentration of fentanyl citrate up to 30micrograms/mL
• Is compatible with morphine sulfate for up to 24 hours, at a concentration of midazolam hydrochloride up to 2mg/mL and a concentration of morphine sulfate up to 8mg/mL, with sodium chloride 0.9% used as a diluent

The information on this page has been put together rapidly to help colleagues during the COVID-19 pandemic, if you spot anything that’s wrong or needs improving report a concern.