During COVID-19 mixing drugs in a syringe may be more necessary than normal. For our background page on syringe compatibility during COVID-19 go here.
Midazolam hydrochloride is a solution for injection with an acid pH.
This page gives specific information on compatibility of midazolam hydrochloride when combined with other medicines in a syringe. Use this information in conjunction with the detailed information on midazolam hydrochloride in the national injectable medicines guide.
Known compatibility information for midazolam hydrochloride
- Is compatible with alfentanil hydrochloride for up to 24 hours, at a concentration of midazolam hydrochloride up to 0.2mg/mL and at a concentration of alfentanil hydrochloride up to 0.5mg/mL, with sodium chloride 0.9% used as a diluent
- Is compatible with alfentanil hydrochloride for up to 12 hours, at a concentration of midazolam hydrochloride up to 1.1mg/mL and a concentration of alfentanil hydrochloride up to 2.7mg/mL, with sodium chloride 0.9% used as a diluent
- Is compatible with fentanyl citrate for up to 24 hours, at a concentration of midazolam hydrochloride up to 2.5mg/mL and a concentration of fentanyl citrate up to 30micrograms/mL
- Is compatible with morphine sulfate for up to 24 hours, at a concentration of midazolam hydrochloride up to 2mg/mL and a concentration of morphine sulfate up to 8mg/mL, with sodium chloride 0.9% used as a diluent
Our advice is constantly reviewed as the pandemic situation evolves; if you spot anything that’s wrong report a concern to us.