Preparing Comirnaty Bivalent vaccine

Ian Allen, Pharmacy Quality Assurance Regional Specialist (NW), North West Pharmaceutical Quality AssurancePublished Last updated See all updates

An example SOP for preparing Comirnaty Bivalent vaccine

Example Procedure

Comirnaty Bivalent vaccine must be prepared carefully following the manufacturer’s instructions.

We have produced an example template Standard Operating Procedure (SOP) for the preparation of the Comirnaty Bivalent vaccine. The attachment is presented in Word to enable adaptation locally, or as reference source to check that existing local procedures are robust and comprehensive. Within the SOP, red text indicates where detail is to be added locally.

Attachments

Changes to preparation procedures August 2022

Prior to August 2022, SPS preparation SOPs were specific to the location of preparation (e.g. hospital or PCN), and included a short form preparation work instruction.

As the process of preparing the Comirnaty Bivalent vaccine is the same wherever the vaccine is prepared these procedures have now been consolidated into one preparation SOP for each vaccine. We have withdrawn the shortform work instructions.

Sites may continue to use their existing localised SOPs for the vaccines that they already have in use, and use these resources to revise them as part of their regular review process. Alternatively, sites may start using the new August 2022 SOPs immediately.

Change history

  1. Added statement regarding removal of multiple vials from refrigerator
  1. ‘Steps to be repeated’ amended as it is not necessary to invert vial between doses
  1. Update to number of dose withdrawals allowed to 6 and max storage temp after first use to 30C
  1. Published