Preparing Comirnaty Original / Omicron BA.4-5

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An example SOP for preparing Comirnaty Original / Omicron BA.4-5 vaccine

Example Procedure

Comirnaty Original / Omicron BA.4-5 vaccine must be prepared carefully following the manufacturer’s instructions.

We have produced an example template Standard Operating Procedure (SOP) for the preparation of the Comirnaty Original / Omicron BA.4-5 vaccine. The attachment is presented in Word to enable adaptation locally, or as a reference source to check that existing local procedures are robust and comprehensive. Within the SOP, red text indicates where detail is to be added locally.

Attachments

A slide deck summarising SPS outputs and resources. It should be distributed to relevant healthcare professionals and their teams.
Labetalol, metoprolol or propranolol are the beta-blockers of choice during breastfeeding. Recommendations apply to full term and healthy infants only.
Nifedipine and verapamil are the calcium-channel blockers of choice during breastfeeding. Recommendations apply to full term and healthy infants only.
Guidance on clozapine administration including crushing tablets, importance of not missing doses and practical considerations regarding switching formulations
Morphine is the strong opioid analgesic of choice for treating pain in breastfeeding. Recommendations apply to full term and healthy infants only.

Update history

  1. Section 4.3/4.4 of SOP updated so that vaccine inversion step only takes place once and is not repeated.
  1. Section 4.4.11 Added additional explanation of why 6 hour shelf life is recommended.
  1. Published