Preparing COVID-19 Vaccine AstraZeneca in Trusts

Mark Cheeseman, Professional Lead for Medicines Information, Midlands & East, Midlands and East Medicines Advice Service (East site)Published Last updated See all updates

Resources to support the COVID-19 Vaccine AstraZeneca are provided including: standard operating procedures, work instructions and a checklist.


Attached to this page are:

  • A standard operating procedure describing preparation of the vaccine.
  • A preparation work instruction sheet for the vaccine.
  • A supervision checklist for preparation of the vaccine.


The attachment is presented in Word to enable adaptation locally, or as reference source to check that existing local procedures are robust and comprehensive.
Within the SOP:

  • GREEN TEXT indicates that detail is awaited, and will be added when available;
  • RED TEXT indicates where detail is to be added locally.


Other handling content for Trusts

Other COVID-19 vaccines resources

What to do if you still have questions

If you still have questions you can get in touch with us. However, please first read our service remit; and if you still think we can help, use the email address below.

We're supporting healthcare professionals in England with pharmaceutical aspects of the COVID-19 vaccination programme; read our service remit to find out more.
If you're a healthcare professional in England, get in touch with us if you still have questions

Change history

  1. Resources checked and information remains correct.
  1. Resources checked and information remains correct.
  1. AZH3 Amended to state that outer packaging must be disposed of as confidential waste.
  1. AZH3 4.3.13 Change of zero character with Celsius character.
  2. AZH3 Wording amended in section 4.3.12 to 4.3.14 for clarity on actions required.
  1. AZH3 Wording amended on section 4.3.14 to 4.3.15 providing further clarity on actions required.
  2. AZH3.1 Picture of syringe updated
  1. Amended needle gauge options for morbidly obese patients in accordance with PHE guidance.
  2. Clarification of wording about removing of vaccine vials from refrigerator.
  3. Avoidance of pooling added.
  1. Clarification on working under the national PGD and inclusion of extra consumables for additional doses incorporated into main text.
  1. Withdrawing additional doses information added.
  1. Published