Preparing the Pfizer-BioNTech COVID-19 Vaccine at PCN designated sites

Amanda Cooper, Associate Director, Medicines Use and Safety TeamPublished Last updated See all updates

Standard Operating Procedure for preparation of the Pfizer-BioNTech COVID-19 Vaccine in PCN designated sites prior to immediate administration.


A standard operating procedure is attached to this page.

You should also familiarise yourself with our background guide Facilitating pharmaceutical support to PCN designated sites before using this SOP.


Other external resources

Pfizer Vaccine Handling and Preparation Video

28 January 2021A video produced by Pfizer showing the correct handling and preparation of the Pfizer COVID-19 vaccine

What to do if you still have questions

If you still have questions you can get in touch with us. However, please first read our service remit; and if you still think we can help, use the email address below.

We're supporting healthcare professionals in England with pharmaceutical aspects of the COVID-19 vaccination programme; read our service remit to find out more.
If you're a healthcare professional in England, get in touch with us if you still have questions

Change history

  1. Link to Pfizer video added

  2. PVH3 - Needle gauge options for morbidly obese amended, avoidance of pooling added and amended to six doses in line with updated regulation 174

  3. PVH3.1 - Amended in line with updated regulation 174

  4. PVH3.2 - Amended in line with updated regulation 174

  5. PVH3.2 - In line with PVH3 version 2.4 update. Minor clarifications and addition of consumables for sixth dose added into main text

  6. PVH3 - 5.4.4 - Word “new” added

  7. PVH3 - 5.4.1 - Additional consumables for sixth dose added

  8. PVH3 - 5.3.1 - Clarification of swab type

  9. PVH3 - 5.1.7 - Clarification of second check

  10. PVH3 - 3 - Wording reflects availability of National Protocol

  11. Published