Propofol: syringe compatibility information for use during COVID-19

During COVID-19 mixing drugs in syringes may be more necessary than normal.  For our background page on syringe compatibility during COVID-19 go here.

Propofol is presented in a variety of forms as an aqueous isotonic oil-in-water emulsion and has an acid to base pH.

Mixing propofol with other medicines is high risk.  All propofol formulations are emulsions and hence signs of physical incompatibility may be masked.  In addition, pH and formulation vary between manufacturers, making extrapolating compatibility between products complex.

This page gives specific information on compatibility of propofol when combined with other medicines in a syringe.  Use this information in conjunction with the detailed information on propofol in the national injectable medicines guide.

Known compatibility information for propofol

  • The Diprivan brand of propofol 1% is compatible with alfentanil hydrochloride for up to 6 hours, at a concentration of up to 10mg/mL of propofol and up to 500microgram/mL of alfentanil hydrochloride in the ratio of 20:1 to 50:1 v/v.
  • The Diprivan brand of propofol 1% is compatible with fentanyl citrate for up to 90 minutes at a concentration of up to 9.5mg/mL of propofol and up to 2microgram/mL of fentanyl citrate.
  • The Fresenius Kabi brand of propofol 1% and propofol 2% is compatible with fentanyl citrate for up to 12 hours, at a concentration of up to 20mg/mL of propofol and up to 50micrograms/mL of fentanyl citrate.
  • Is incompatible with morphine sulfate.

The information on this page has been put together rapidly to help colleagues during the COVID-19 pandemic, if you spot anything that’s wrong or needs improving report a concern.