Safety in Lactation: Antimuscarinic drugs

Sarah Fenner, Acting Co-Director, Midlands and East Medicines Advice Service (West Midlands site) & UK Drugs in Lactation Advisory ServicePublished

These antimuscarinics are used as premedication, to dry secretions, and for intraoperative bradycardia. They are given as a single dose by injection, repeated if necessary for bradycardia.
Their properties suggests that little drug will appear in milk or be subsequently absorbed by the infant. It is therefore considered that breastfeeding can be resumed as soon as the mother has recovered sufficiently from the effects of general anaesthesia. Single-dose use and delayed resumption of breastfeeding will mitigate any increased sensitivity to anticholinergics in infants. Consider possible risks associated with other drugs used in association with inhalational anaesthetics.