Safety in Lactation: Drugs used in status epilepticus

Sarah Fenner, Acting Co-Director, Midlands and East Medicines Advice Service (Midlands site) & UK Drugs in Lactation Advisory ServicePublished

Choice of treatment will be influenced by the clinical situation. The evidence for these drugs in breastfeeding is based on their longer-term use rather than short-term or intermittent use for status epilepticus.
Benzodiazepines and midazolam are used first-line, with a single dose repeated once if necessary. When used in this way the mother may resume breastfeeding when she is capable.
Combination therapy may pose an increased risk to the infant, especially when adverse effects, such as drowsiness, are additive.
All infants should be monitored for sedation. Poor feeding, adequate weight gain, and developmental milestones should be monitored if therapy is prolonged.