Safety in Lactation: Other immunomodulating drugs

Laura Kearney, Regional Principal Medicines Information Pharmacist, Midlands and East Medicines Advice Service (Midlands site) & UK Drugs in Lactation Advisory ServicePublished

Several drugs in this section (dimethyl fumerate, interferon beta, fingolimod, glatiramer, natalizumab) are used in multiple sclerosis (MS) but are not normally interchangeable as they are used at different stages of disease. Breastfeeding appears to have beneficial effects to a mother with MS.
Interferons appear to be compatible with breastfeeding as they are present in milk in low levels, poorly absorbed by the infant.
Drugs used for neoplastic conditions may be used in combination with other antineoplastics which may pose an increased risk to the infant, especially when adverse effects are additive. In these situations, it is advised that specialist advice is sought.