Safety in Lactation: Quinolones

Sarah Fenner, Acting Co-Director, Midlands and East Medicines Advice Service (Midlands site) & UK Drugs in Lactation Advisory ServicePublished

Quinolones are generally accepted for use during breastfeeding, with caution.
There have been concerns about adverse effects on infants’ developing joints, although this has only been reported in infants taking quinolones directly.
The calcium in breast milk may prevent or reduce infant absorption of quinolones.
Avoid in infants with known G6PD deficiency due to the risk of haemolysis. Use with caution in infants with epilepsy
Monitor infant for gastro-intestinal disturbances and oral candida infection, especially if used in high doses, although these effects are unlikely to occur.
Choice of alternatives may be directed by local antimicrobial policy.