Safety in Lactation: Sulphonamides and trimethoprim

Sarah Fenner, Acting Co-Director, Midlands and East Medicines Advice Service (West Midlands site) & UK Drugs in Lactation Advisory ServicePublished

The use of sulphonamides is decreasing due to bacterial resistance and the availability of less toxic antibacterials.
Generally sulphonamides and trimethoprim are acceptable to use whilst breastfeeding full term and healthy infants. Monitor infant for gastro-intestinal disturbances and oral candida infection, especially if used in high doses, although these effects are unlikely to occur.
Choice of alternatives may be directed by local antimicrobial policy.