What are the reported incidences of ankle oedema with different calcium channel blockers?

· Regional Drug and Therapeutics Centre

The potential to cause ankle oedema appears to exist for all calcium channel blocking agents, and is caused by increasing capillary pressure leading to leakage of fluids into the surrounding tissues. This occurs in spite of the diuretic nature of some CCB agents.

Ankle oedema appears to occur more frequently in CCBs from the DHP group, although some agents such as lacidipine and lercanidipine may cause it less frequently than nifedipine and amlodipine.  Diltiazem, a non-DHP agent, seems to be associated with the lowest incidence of ankle oedema.

This Q&A lists the reported incidences of ankle oedema with calcium channel blockers licensed in the UK.

For information regarding the how to manage ankle oedema caused by CCBs a specific UKMi Q&A has been published: ‘How should ankle oedema caused by calcium channel blockers be treated?

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