There appears to be a link between bisphosphonate use and an increased risk of serious inflammatory ocular disorder such as uveitis and scleritis. The absolute risk of such events remains low, but there is currently little data on which to estimate incidence rates.
Non-nitrogen containing bisphosphonates may theoretically be less likely to cause ocular effects than those which contain nitrogen groups.
Patients who develop eye pain or vision disturbances should receive prompt treatment. Discontinuation of the bisphosphonate is likely to be required.