What factors need to be considered when dosing patients with renal impairment?

Michele Skipp, Senior Medicines Information Pharmacist, South West Medicines Information and TrainingPublished

** THIS DOCUMENT IS UNDER REVIEW**

Many commonly used drugs or their metabolites are excreted by the kidney, and this has particular significance for people with renal impairment (RI). Impaired renal function alters drug pharmacokinetics, potentially changing drug efficacy and increasing the likelihood of unwanted effects, including renal toxicity. There may also be pharmacodynamic changes.

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