What is the most appropriate antidepressant to use in people with epilepsy?

· UKMi

NICE recommend that non-pharmacological interventions such as CBT should be considered in people presenting with depression, in addition to the use of antidepressants. With respect to antidepressants, resources suggest that SSRIs are an appropriate first-line choice for treating depression in people with epilepsy. This updated Medicines Q&A evaluates the published information available on the most appropriate choice of antidepressant for people with epilepsy.

AgomelatineAmitriptylineCitalopramClomipramineDosulepinDoxepinDuloxetineEscitalopramFluoxetineFlupentixol decanoateFlupentixol dihydrochlorideFluvoxamineImipramineIsocarboxazidLofepramineMental HealthMianserinMirtazapineMoclobemideNeurological disordersNortriptylineParoxetinePhenelzineQ&AReboxetineSertralineTrazodoneTrimipramineVenlafaxine

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