• Topical (applied to the skin) treatments for acne are considered to be safer than oral treatments in people with an acute form of porphyria, provided they are applied to intact skin.
  • Topical retinoids, benzoyl peroxide and topical antibiotic creams are known to be safe in acute porphyria for people with mild and moderate acne.
  • Oral erythromycin and oral contraceptives (oestrogens and progestogens) are known to be porphyrinogenic (cause acute attacks) and should be avoided in people with an acute form of porphyria who require treatment for acne.