- The causes and pathophysiology of PD are not clear at this time. It is therefore difficult to find a reliably effective oral treatment.
- Vitamin E, potassium para-aminobenzoate, colcichine, tamoxifen, pentoxifylline, and acetyl-L-carnitine have all been investigated as treatment options.
- No oral treatment has a robust evidence base supporting its use at this time. Some evidence is conflicting as to the effectiveness of treatments, but there are methodological limitations in much of the available literature.
- More large, robust clinical trials are required to determine effectiveness of oral treatments.
- Individual patients may benefit from oral treatments, but the current evidence base is too limited to determine which patients may benefit most.
Medicines Information Scientist, RDTC