This updated Medicines Q&A presents a table of the medicines considered safe for use in the acute porphyrias. Inclusion of a drug does not guarantee that it will be safe in all circumstances.

The following medicines have been added as SAFE:

  • Anidulafungin
  • Aripiprazole
  • Benralizumab
  • Betahistine
  • Calcium polystyrene sulfonate
  • Cefepime
  • Cefoxitin
  • Cinacalcet
  • Demeclocycline
  • Diclofenac
  • Dimeticone
  • Ertugliflozin
  • Ivabradine
  • Linaclotide
  • Meropenem with vaborbactam
  • Midodrine
  • Paliperidone
  • Prazosin
  • Prucalopride
  • Quetiapine
  • Simeticone
  • Sodium zirconium cyclosilicate
  • Tigecycline

See attachments for a full list of medicines considered to be safe, now provided as a list of all medicines in alphabetical order and the same list again but with medicines divided under their relevant treatment categories.

No drugs have been removed from the list due to concerns about safe use in porphyria.

The following deletions have been made because these products are no longer readily available in UK practice:

  • Abciximab
  • Cyclopenthiazide
  • Norfloxacin