Shortage of Heminevrin (clomethiazole) 192 mg capsules

Cheplapharm, the sole manufacturer of clomethiazole capsules are out of stock until the middle of September. They also manufacture the 31.5 mg/ml syrup but do…

Shortage of Actiq lozenges and Instanyl nasal spray (immediate-release fentanyl citrate)

Actiq lozenges and Instanyl nasal spray are both licensed for the treatment of breakthrough pain in adults with cancer who are already receiving maintenance opioid…

Cardiovascular outcomes with GLP-1 receptor agonists

This document reviews the evidence from the major cardiovascular clinical trials for GLP-1 receptor agonists.

Written Instruction for the administration of seasonal 'flu vaccination

Following advice issued in Spring 2018 advising on the use of Patient Group Directions in Occupational Health Services, SPS became aware of issues being encountered…

Adalimumab: procurement and reference pricing FAQ

See below for an FAQ document produced through the RMOC system on adalimumab. It includes detail on the procurement process, its outcome and implementation.

What is a suitable combined oral contraceptive pill in a patient who is taking hepatic enzyme-inducing drugs, such as carbamazepine, phenytoin, rifampicin or rifabutin?

This updated Medicines Q&A provides advice on a suitable oral contraceptive that can be used in a woman using an enzyme-inducing anti-epileptic or anti-tubercle drug.…

Evidence for use of siltuximab or anakinra as second line therapies (after failure of tocilizumab) for Cytokine Release Syndrome following use of Chimeric Antigen Receptor T-cell (CAR-T) therapy

CAR-T therapy often causes cytokine release syndrome (CRS) which is treated with tocilizumab as first-line therapy. Tocilizumab is licensed for this indication but in some…