Shortage of metoprolol 50mg and 100mg tablets

There are intermittent supply issues as some manufacturers have recently discontinued these products and others are having supply difficulties. Supplies of both strengths are currently available…

Tamoxifen and SSRI or SNRI antidepressants – is there an interaction?

This updated Medicines Q&A reviews the evidence for an interaction between tamoxifen and selective serotonin reuptake inhibitors (SSRIs)/serotonin noradrenaline reuptake inhibitors (SNRIs) resulting in reduced…

Fluoride toothpaste – what are the dangers of chronic ingestion in adults?

This Medicines Q&A examines the effects of chronic fluoride ingestion associated with use of fluoride toothpaste in adults.

Maintaining Patency of Central Venous Catheters in Adults: RMOC Position Statement

The Regional Medicines Optimisation Committee (RMOC) (London) reviewed the role of heparinised saline lock versus sodium chloride 0.9% lock for maintaining patency of central venous…

Shortage of Madopar 50 mg/12.5 mg Dispersible Tablets

Roche, the sole supplier, is not expecting further stock until mid-end February. They have confirmed that good supplies of Madopar 100 mg/25 mg dispersible tablets remain…

Shortage of urokinase injection (Syner-KINASE®) 10,000 IU, 25,000 IU and 100,000 IU Powder for solution for injection or infusion

The supply issue with urokinase injection (Syner-kinase) will affect all strengths and last for several months due an issue at the manufacturing site. Syner-Med is…