Methotrexate

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What injections can be given orally or via enteral feeding tubes?

6 November 2020This updated Medicines Q&A is a quick reference summary to different types of enteral feeding tubes, in relation to medication issues. Not all enteral feeding…

What is the clinical significance of the interaction between methotrexate and penicillins?

1 October 2020The evidence for an interaction between methotrexate and penicillins is limited to case reports and animal studies. So far, there is no conclusive evidence that…

Suggestions for Therapeutic Drug Monitoring in Adults in Primary Care

29 September 2020This document is intended to support local discussions on how to monitor commonly prescribed high risk medicines in primary care.    The monitoring parameters cited…

Safety in Lactation: Antimetabolites

23 September 2020Antineoplastic antimetabolites, whether used as monotherapy or in combination with other antineoplastics, are contra-indicated in breastfeeding (except where indicated below) because of their effects on…

Should patients drink alcohol whilst taking long-term low-dose methotrexate?

22 September 2020This Medicines Q&A reviews the evidence that alcohol increases risk of methotrexate-induced liver toxicity, and advises on safe levels of alcohol intake by patients taking…

Safety in lactation: Drugs for chronic bowel disorders

21 September 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Aminosalicylates for chronic bowel disorders Mesalazine…

Methotrexate dosing in renal impairment – more awareness and action needed

15 April 2019Chronic kidney disease impacts upon prescribing for some disease modifying anti-rheumatic drugs. Methotrexate is usually hospital-initiated but rheumatology and dermatology patients will be monitored by…

Safety in Lactation: Systemic preparations for eczema and psoriasis

7 January 2019Drugs used orally or parenterally for severe eczema and psoriasis have a varied pharmacology, mainly either modifying the immune response to the disease or modifying…

What should people do if they miss a dose of their medicine?

1 August 2018Sometimes patients forget to take their medicines at the normal time. This may cause a problem because missing a dose may make the medicine less…

What is the Dose of Folic Acid to use with Methotrexate therapy for Rheumatoid Arthritis?

5 October 2012This updated Q&A notes that there remains no definitive answer regarding the optimal dose of folic acid for patients with rheumatoid arthritis who are being…