How should medicines be dosed in children who are obese?

Obesity results in physiological changes that can affect the volume of distribution and the clearance of drugs. The extent of these changes is variable and…

What advice should be given to people with porphyria who are undergoing dental procedures?

An indication of the safety of various medicines commonly used by dentists in patients with acute porphyria is given. When considering the safety of medicines…

Do proton pump inhibitors reduce the clinical efficacy of clopidogrel?

This updated Medicines Q&A evaluates the available evidence for an interaction between clopidogrel and proton pump inhibitors  

Is there an interaction between warfarin and proton pump inhibitors?

This updated Medicines Q&A evaluates the evidence for an interaction between warfarin and proton pump inhibitors.  

Is there an interaction between bisphosphonates and proton pump inhibitors?

This updated Medicines Q&A evaluates the evidence for an interaction between bisphosphonates and proton pump inhibitors.  

Safety in Lactation: Drugs for disorders of gastric acid and ulceration

Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Drugs for dyspepsia Aluminium and magnesium…

Clostridium difficile infection – is use of proton pump inhibitors a risk factor?

Clostridium difficile infection (CDI) is associated with considerable morbidity and risk of mortality. Risk factors for CDI include antibiotic use, hospitalisation, advanced age, underlying morbidity…

Proton-pump-inhibitors for treatment of reflux in a breastfeeding mother: which is preferred?

There is limited experience with the use of omeprazole and pantoprazole during lactation. Milk levels for both drugs are low, and in addition a large…