NOACs and Antidepressants – What are the risks of using these together and how should these risks be managed?

This article considers the risk of interactions between NOACs and antidepressants. ·        Non-vitamin K antagonist oral anticoagulants (NOACs) appear to have fewer clinically significant drug…

Statins - What is the evidence for their use in patients with renal impairment?

This Q&A evaluates the evidence for the use of statins in renal impairment and discusses current guidance for using statins in this population.

Which medicines prevent acute mountain sickness?

This Medicines Q&A discusses the use of medicines that can be used to prevent acute mountain sickness, including acetazolamide, dexamethasone, and gingko biloba.

Can Nursing Associates and Physician Associates operate under a Patient Group Direction?

Only those professions listed in legislation can operate under a Patient Group Direction (PGD). Neither Nursing Associates nor Physician Associates are currently included within the…

What clinical evidence is there to support the use of desiccated thyroid extract products?

This updated Medicines Q&A evaluates the clinical evidence for the use of desiccated thyroid extract products including ‘Armour thyroid’

Can high dose loperamide be used to reduce stoma output?

Some patients with a stoma resulting from an ileostomy, jejunostomy or a colostomy, can experience high-volume liquid stoma output.  This Medicines Q&A evaluates the limited…

Is there a 10% cross-sensitivity between penicillins and cephalosporins?

This Q&A investigates whether the often-stated 10% cross-sensitivity between penicillins and cephalosporins is supported by clinical evidence.

What is the antidepressant of choice in coronary heart disease (CHD)?

This updated Q&A describes the limited data on antidepressant use in patients with coronary heart disease.

How do you convert from co-beneldopa (Madopar®) prolonged-release capsules to dispersible tablets?

For patients taking the prolonged-release preparation of co-beneldopa (Madopar® CR), there may be clinical situations when an alternative formulation of co-beneldopa needs to be considered…

Can small volume intramuscular injections be given to patients taking oral anticoagulants?

This Medicines Q&A discusses the potential risks associated with the administration of small volume IM injections to patients taking oral anticoagulants. It has been partially…