Which opioids can be used in renal impairment?

Opioids are used in a wide variety of clinical settings and are well established for the treatment of both acute and chronic pain. Renal impairment…

What is the risk of interaction between opioids and monoamine oxidase inhibitors (MAOIs)?

This article considers the risks of interaction between opioids and monoamine oxidase inhibitors. The use of MAOIs with opioids is contraindicated or cautioned by manufacturers.…

What is the first choice antidepressant for patients with renal impairment?

This updated Medicines Q&A evaluates the limited published evidence available on the use of antidepressants in patients with renal impairment. The use of antidepressants in…

Which medicines require extra care when switching between liquid and tablet/capsule formulations?

For a small number of medicines, there are differences in equivalent doses of oral formulations of the same medicine. This Q&A considers which medicines may…

NOACs and Antidepressants – What are the risks of using these together and how should these risks be managed?

This article considers the risk of interactions between NOACs and antidepressants. ·        Non-vitamin K antagonist oral anticoagulants (NOACs) appear to have fewer clinically significant drug…

Statins - What is the evidence for their use in patients with renal impairment?

This Q&A evaluates the evidence for the use of statins in renal impairment and discusses current guidance for using statins in this population.

Which medicines prevent acute mountain sickness?

This Medicines Q&A discusses the use of medicines that can be used to prevent acute mountain sickness, including acetazolamide, dexamethasone, and gingko biloba.

Can Nursing Associates and Physician Associates operate under a Patient Group Direction?

Only those professions listed in legislation can operate under a Patient Group Direction (PGD). Neither Nursing Associates nor Physician Associates are currently included within the…

What clinical evidence is there to support the use of desiccated thyroid extract products?

This updated Medicines Q&A evaluates the clinical evidence for the use of desiccated thyroid extract products including ‘Armour thyroid’

Can high dose loperamide be used to reduce stoma output?

Some patients with a stoma resulting from an ileostomy, jejunostomy or a colostomy, can experience high-volume liquid stoma output.  This Medicines Q&A evaluates the limited…