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Mental health and illness

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Clozapine use in adults with swallowing difficulties

19 May 2026Guidance on clozapine administration including crushing tablets, importance of not missing doses and practical considerations regarding switching formulations

Implementing a process to deprescribe an antidepressant

13 May 2026The process requires care and continual review. You should plan, discuss and agree a shared strategy with the patient.

Planning for antidepressant deprescribing

13 May 2026Before undertaking antidepressant withdrawal, you should plan, discuss and agree a shared strategy with the patient.

Identifying patients who may benefit from antidepressant deprescribing

13 May 2026Use a shared-decision approach to regularly review a patient's antidepressant use to assess whether it remains appropriate or requires deprescribing.

Using suitable formulations when deprescribing antidepressants

13 May 2026Tapering antidepressants to very low doses poses practical challenges. This page outlines licensed, off-label and unlicensed options.

SSRI suggestions for adults with swallowing difficulties

27 April 2026A range of selective serotonin reuptake inhibitor (SSRI) formulations are suitable for adults with swallowing difficulties.

Choosing an antidepressant for people with epilepsy

26 March 2026Selective serotonin reuptake inhibitors (SSRIs) are the preferred antidepressant in people with epilepsy. We give considerations when selecting antidepressants.

Addressing inappropriate use of antidepressants for depression and anxiety

20 January 2026Deprescribing antidepressants involves safely reducing and withdrawing them. An introduction; signposting to current resources; and SPS resources coming soon.

Prescribing and switching between modified-release methylphenidate

28 August 2025Modified-release methylphenidate capsules and tablets differ. Ensure patients receive appropriate treatment, particularly during periods of supply disruption.

Using antipsychotics during breastfeeding

14 July 2025Quetiapine is the preferred second-generation, and haloperidol the preferred first-generation antipsychotic when breastfeeding full term, healthy infants.