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Articles

Safety in Lactation: Anxiolytics.

21 October 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Use of anxiolytics in breastfeeding mothers…
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Medicine Compliance Aid Stability

XanaxPharmacia Ltd

Pharmacia Ltd
Xanax
Tablets 250 micrograms, 500 micrograms
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Protect from light
Protect from light.
1 October 2015

Lactation Safety Information

Lorazepam, Oxazepam
Shorter-acting agent
Very limited published evidence of safety which indicates small amounts in breast milk
Adverse effects reported include infant withdrawal following maternal discontinuation, and sedation
Monitor the infant closely for drowsiness, poor feeding and adequate weight gain
18 September 2020

New Medicines

Epilepsy in patients with stereotypical prolonged seizures aged 12 years and older - inhaler formulation

Information

New formulation
UCB Pharma
UCB Pharma

Development and Regulatory status

None
None
Phase III Clinical Trials

Category

A positive allosteric modulator of multiple γ-aminobutyric acid type A (GABAA)-receptor subtypes Alprazolam is thought to mediate its anti-seizure effects through the inhibitory effect of GABA in the CNS. Given as a single 2mg dose.
The prevalence of active epilepsy is 5-10 cases per 1,000 - but with 5-30% of these misdiagnosed as having epilepsy. Incidence varies with age, with the highest risk in infants and people over the age of 50 years. The incidence of new-onset epilepsy in elderly people is increasing [1].
Epilepsy in patients with stereotypical prolonged seizures aged 12 years and older - inhaler formulation
Inhalation