Ammonia oxidizing bacteria

Unassigned

New Medicines

Mild-to-moderate acne vulgaris - topical spray formulation

Information

Microbiome-targeted therapy
AOBiome Therapeutics
AOBiome Therapeutics

Development and Regulatory status

None
None
Phase III Clinical Trials

Category

Designed to repopulate skin microbiome with AOB which is normally found on the body. Once deployed, AOB convert ammonia to nitrite, which is known to have antibacterial properties, and to nitric oxide, which regulates inflammation and vasodilation. [2]
Acne affects more than 80% of people at some point in their life, up to 14% of whom consult their GP and approximately 3.5 million consultations with GPs occur in the UK annually for acne. Morbidity can be high and associated with disfigurement, pain, loss of confidence, and impairment of normal social and workplace function, with documented effects on quality of life including depression, dysmorphobia, and suicide [1].
Mild-to-moderate acne vulgaris - topical spray formulation
Topical