APL2

Unassigned

New Medicines

Dry age-related macular degeneration (AMD)

Information

New molecular entity
Apellis
Apellis

Development and Regulatory status

None
None
Phase III Clinical Trials

Category

A derivative of compstatin, a cyclic peptide that inhibits complement activation at the level of complement factor C3
Prevalence is estimated at approximately 1 per 500,000. PNH is a chronic disease with hemolytic crises that may be triggered by several factors such as vaccination, surgery, certain antibiotics, and infections. Bone marrow failure may occur initially or as a late complication of the disease (20% of cases) [1].
Dry age-related macular degeneration (AMD)
Intravitreal