Articles · Medicine Compliance Aid Stability · Lactation Safety Information ·



Drug-induced hypersalivation – what treatment options are available?

This Medicines Q&A summarises published studies or case reports concerning the pharmacological treatment of drug-induced hypersalivation (drooling or sialorrhoea), particularly hypersalivation caused by clozapine.   Amisulpride Atropine Benzatropine Biperiden Botulinum A toxin Bupropion Clonidine Clozapine Glycopyrronium Guanfacine Hyoscine butylbromide Hyoscine hydrobromide Ipratropium Lofexidine Metoclopramide Moclobemide Oxybutynin Pirenzepine Propantheline Q&A Quetiapine Sulpiride Trihexyphenidyl

Medicine Compliance Aid Stability

generic · Wockhardt UK Ltd

Wockhardt UK Ltd
Tablets 600 micrograms
R2 · Red 2 · Drug is not suitable for CAs due to theoretical reasons that cannot be mitigated.
Atropine effloresces on exposure to dry air and is slowly affected by light.
6th November 2015

Lactation Safety Information

As GI antispasmodic

As GI antispasmodic
Propantheline; Mebeverine
No published evidence of safety
Low levels anticipated in milk due to the drug’s properties
Short-term use unlikely to affect lactation. However, long-term use may theoretically carries higher risk than other anticholinergics due to the drug’s properties. See summary for further information on anticholinergic affects
14th July 2016

For premedication and bradycardia

For premedication and bradycardia
Low levels anticipated in milk due to the drug's properties
No published evidence of safety

For ophthalmic use

For ophthalmic use
Tropicamide as diagnostic, Homatropine or cyclopentolate for longer-term use
Short-term use as a diagnostic considered to pose negligible risk, although has very long (7 days) duration of action
Longer-term use has theoretical risks – see summary