Autologous BM derived stem cell therapy

Unassigned

New Medicines

NurOwn · Amyotrophic lateral sclerosis (motor neurone disease)

Information

NurOwn
Advanced therapy medicinal product (ATMP)
BrainStorm Cell Therapeutics
BrainStorm Cell Therapeutics

Development and Regulatory status

None
None
Phase II Clinical Trials
Yes
Yes

Category

Autologous bone marrow-derived mesenchymal stem cells (MSC) - stimulated to differentiate into astrocyte-resembling cells expressing astrocytic markers and neurotrophic factors, such as GDNF, BDNF, VEGF and HGF, to replace and/or protect existing cells
MND is relatively uncommon with an annual incidence of about 2 cases per 100,000 population. Prevalence is about 5-7 per 100,000. General practitioners can expect to see one or two cases in their career [1].
Amyotrophic lateral sclerosis (motor neurone disease)
Intramuscular and
Intrathecal