PIII ECHELON-2 published. Median progression-free survival was 48.2 months in the Brentuximab+CHP group and 20.8 months in the CHOP group (p=0.011) .
Positive results from PIII ECHELON-2 trial announced. The randomized, double-blind, placebo-controlled multiccentre trial enrolled ~450 pts. Brentuximab Vedotin + CHP (cyclophosphamide, doxorubicin, prednisone) vs. CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), achieved the primary endpoint, demonstrating improvement in Progression-Free Survival (hazard ratio=0.71; p=0.0110). Improvements were achieved in all Key secondary endpoints, including overall survival.
NCT01777152 due to complete Dec 18 .
NCT01777152 ECHELON-2 Data are expected in 2017 to 2018 timeframe. 
PIII ECHELON-2 study still rectruiting - no results have been reported .
The PIII study (NCT01777152) is enrolling 300 patients. The estimated completion date is Dec 19 with primary outcome data available Dec 17 .
The PIII global ECHELON-2 study evaluating brentuximab vedotin in combination with chemotherapy in patients with newly diagnosed CD30-positive mature T-cell lymphoma (MTCL), including patients with systemic anaplastic large cell lymphoma (sALCL) and other types of peripheral T-cell lymphomas has started. The trial has a Special Protocol Assessment (SPA) agreement from FDA and has received scientific advice from the EMA. In the randomized, double-blind, study, brentuximab in combination with cyclophosphamide, doxorubicin and prednisone (A+CHP) will be compared to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) as 1st-line therapy in 300 patients with CD30-expressing MTCL. The primary endpoint is progression-free survival per independent review facility assessment. Secondary endpoints include overall survival (OS), complete remission (CR) rate and safety. A molecular companion diagnostic test will be used to identify eligible patients based on CD30 expression; this is being developed in collaboration with Ventana Medical Systems .