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Safety in Lactation: Diuretics

Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Thiazides and related diuretics (includes bendroflumethiazide,… Acetazolamide Amiloride Bendroflumethiazide Bumetanide Cardiovascular system disorders Chlortalidone Eplerenone Furosemide Hydrochlorothiazide Indapamide Mannitol Metolazone Obstetrics and gynaecology Paediatric and neonatal medicine Safety in Lactation Spironolactone Torasemide

Medicine Compliance Aid Stability

generic · Teva UK Ltd

Teva UK Ltd
Tablets 1mg, 5mg
A3 · Amber 3 · No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from light. Store in airtight containers. Bumetanide is photosensitive and will discolor when exposed to light.
9th November 2015

Lactation Safety Information

No published evidence of safety
24th February 2017

New Medicines

Autism in children and adolescents


Re-purposed drug

Development and Regulatory status

Phase III Clinical Trials
Phase III Clinical Trials


Loop diuretic in a oral liquid formulation; ion pump modulator. Some neurodevelopmental disorders are associated with high sodium levels in neurons, which are reduced by bumetanide.
Estimates suggest that about 1% of people in the UK have autistic spectrum disorder (ASD) [3] and a study published in 2013 found UK annual prevalence rates for autism at age 8 of 3.8/1000 for boys and 0.8/1000 for girls, and annual incidence rates for children aged 2-8 of 1.2/1000 and 0.2/1000 respectively, with rates steady from the early 2000s [4].
Autism in children and adolescents