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Using chloramphenicol eye products in children under 2 years

29 April 2021Chloramphenicol eye drops that contain boron or borates (borax or boric acid) can be safely used in children under 2 years where indicated.

Safety in Lactation: Some other antibacterials

4 November 2020Monitor infant for gastro-intestinal disturbances and oral candida infection, especially if used for prolonged periods or in high doses, although these effects are unlikely to…

Safety in Lactation: Anti-infective eye preparations

30 October 2020Anti-infective preparations for ophthalmic use have limited systemic absorption in the mother, and pose negligible risk to a breastfed infant. Systemic absorption from eye drops…

Safety in Lactation: Drugs for otitis externa

17 September 2020Preparations for treating otitis externa have limited systemic absorption in the mother, and pose negligible risk to a breastfed infant. There is no published evidence…

Chloramphenicol: is it safe in breastfeeding?

15 March 2019This updated Medicines Q&A discusses the safety of the antibiotic, chloramphenicol (systemic and ophthalmic), in breastfeeding women.
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Refrigerated Storage

Chloramphenicol Martindale Pharma (Ethypharm Group Company)

Martindale Pharma (Ethypharm Group Company)
Chloramphenicol
Eye drops, 0.5%

Contact Martindale (Ethypharm) in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

Store in a dry place away from strong sunlight and do not freeze.

12 May 2020
London MI Service

ChloramphenicolMartindale Pharma (Ethypharm Group Company)

Martindale Pharma (Ethypharm Group Company)
Chloramphenicol
EAR drops, 5% and 10%

Contact Martindale (Ethypharm) in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

Please refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk

Store in a dry dark place. Do not freeze.

12 May 2020
London MI Service

Minims ChloramphenicolBausch & Lomb

Bausch & Lomb
Minims Chloramphenicol
0.5% eye drops solution

In the event of an inadvertent temperature excursion the following data may be used:
If necessary, the product may be stored at temperatures not exceeding 25°C for up to 1 month only.
Please also refer to the manufacturer’s product literature for recommended storage information at https://www.medicines.org.uk
Contact Bausch & Lomb directly for any additional information in all cases where a deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

1 month
No
6 April 2021
London MI Service

Lactation Safety Information

Oral / Parenteral

Oral / Parenteral
No
Alternative microbiologically appropriate antibiotic
Significant amounts in breast milk
Theoretical risk of aplastic anaemia in the breastfed infant, although only minor adverse effects reported to date.
Monitor infant for gastro-intestinal disturbances and oral candida infection, especially if used for prolonged periods or in high doses, although these effects are unlikely to occur.
16 September 2020
Q&A

For ophthalmic use

For ophthalmic use
Fusidic acid
Theoretical risk of aplastic anaemia in the breastfed infant, although no evidence to support this
Fusidic acid preferred unless clinically inappropriate
16 September 2020
Q&A

For use in the ear

For use in the ear
Gentamicin if clinically appropriate
Theoretical risk of aplastic anaemia in the breastfed infant, although no evidence to support this
16 September 2020