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Equivalent doses of oral benzodiazepines

6 July 2021Benzodiazepines are the most commonly used anxiolytics and hypnotics. There are major differences in potency between different benzodiazepines and this difference in potency is important…

What injections can be given orally or via enteral feeding tubes?

6 November 2020This updated Medicines Q&A is a quick reference summary to different types of enteral feeding tubes, in relation to medication issues. Not all enteral feeding…

Safety in Lactation: Drugs used in status epilepticus

5 November 2020Choice of treatment will be influenced by the clinical situation. The evidence for these drugs in breastfeeding is based on their longer-term use rather than…

Safety in Lactation: Control of epilepsy

21 September 2020Choice will depend on clinical condition, and should primarily be based on suitability for the patient, rather than safety during breastfeeding. Whilst sodium valproate  is…
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Medicine Compliance Aid Stability

genericNon-proprietary

Non-proprietary
generic
Tablets 500 micrograms
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight containers. Protect from light.
2 March 2015

RivotrilRoche Products Ltd

Roche Products Ltd
Rivotril
Tablets 500 micrograms, 2mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Store in airtight containers. Protect from light.
2 March 2015

Lactation Safety Information

Oral for epilepsy

Oral
for epilepsy
Suitable alternative antiepileptic
Limited published evidence of safety
Long half-life increases risk of accumulation in breastfed infants
Apnoea and cyanosis reported in infant exposed in utero and via breast milk
Long term use should be avoided during breastfeeding
30 July 2020

Parenteral for status epilepticus

Parenteral
for status epilepticus
Lorazepam
Limited published evidence of safety
Small amounts in breast milk
Long half-life increases risk of accumulation in breastfed infants with repeated doses
Signs of respiratory depression reported in an infant after exposure in utero and early breastfeeding
Short-term therapy (1-2 doses) considered not to pose a risk to the infant
30 July 2020