Clozapine

Articles · Medicine Compliance Aid Stability · Lactation Safety Information ·
96221003

Articles

Drug-induced hypersalivation – what treatment options are available?

This Medicines Q&A summarises published studies or case reports concerning the pharmacological treatment of drug-induced hypersalivation (drooling or sialorrhoea), particularly hypersalivation caused by clozapine.   Amisulpride Atropine Benzatropine Biperiden Botulinum A toxin Bupropion Clonidine Clozapine Glycopyrronium Guanfacine Hyoscine butylbromide Hyoscine hydrobromide Ipratropium Lofexidine Metoclopramide Moclobemide Oxybutynin Pirenzepine Propantheline Q&A Quetiapine Sulpiride Trihexyphenidyl

Medicine Compliance Aid Stability

Denzapine · Britannia Pharmaceuticals Ltd

Britannia Pharmaceuticals Ltd
Denzapine
Tablets 25mg, 50mg, 100mg, 200mg
A3 · Amber 3 · No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from light. Sensitive to oxygen. Max 28 days in MCA.
1st October 2015

Clozaril · Novartis Pharmaceuticals UK Ltd

Novartis Pharmaceuticals UK Ltd
Clozaril
Tablets 25mg, 100mg
A2 · Amber 2 · No stability data is available, the manufacturer does not, or cannot recommend use in CAs but there are no theoretical concerns with the product.
Airtight container
Max 28 days in MCA. Sensitive to oxygen.
1st October 2015

Zaponex · Leyden Delta BV

Leyden Delta BV
Zaponex
Tablets 25mg, 100mg
A3 · Amber 3 · No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Max 28 days in MCA. Sensitive to oxygen.
1st October 2015

Lactation Safety Information

Quetiapine, Haloperidol
Limited data suggest that clozapine may accumulate in breast milk
Agranulocytosis and delayed speech reported in breastfed infants
9th November 2018