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Switching between liquid and tablet/capsule formulations – Which medicines require extra care?

19 July 2021For a small number of medicines, there are differences in equivalent doses of oral formulations of the same medicine. This needs to be considered when…

Safety in Lactation: Antipsychotics

22 September 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Oral and non-depot antipsychotics with less…

Clozapine drug monitoring during COVID-19 for stable adult patients

2 April 2020This page provides advice on the monitoring and prescribing of clozapine during the COVID-19 pandemic

What are the clinically significant drug interactions with tobacco smoking?

23 March 2020This Medicines Q&A summarises those drug interactions with tobacco smoking that are considered to be most clinically important. Most interactions between drugs and tobacco smoking…

Drug-induced hypersalivation – what treatment options are available?

1 August 2018This Medicines Q&A summarises published studies or case reports concerning the pharmacological treatment of drug-induced hypersalivation (drooling or sialorrhoea), particularly hypersalivation caused by clozapine. Update…
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Medicine Compliance Aid Stability

DenzapineBritannia Pharmaceuticals Ltd

Britannia Pharmaceuticals Ltd
Denzapine
Tablets 25mg, 50mg, 100mg, 200mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from light. Sensitive to oxygen. Max 28 days in MCA.
1 October 2015

ClozarilNovartis Pharmaceuticals UK Ltd

Novartis Pharmaceuticals UK Ltd
Clozaril
Tablets 25mg, 100mg
A2 · Amber 2No stability data is available, the manufacturer does not, or cannot recommend use in CAs but there are no theoretical concerns with the product.
Airtight container
Max 28 days in MCA. Sensitive to oxygen.
1 October 2015

ZaponexLeyden Delta BV

Leyden Delta BV
Zaponex
Tablets 25mg, 100mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Max 28 days in MCA. Sensitive to oxygen.
1 October 2015

Lactation Safety Information

No
Quetiapine, Haloperidol
Limited data suggest that clozapine may accumulate in breast milk
Agranulocytosis and delayed speech reported in breastfed infants
9 November 2018