Colistimethate

Articles · Lactation Safety Information · New Medicines ·
422267005

Articles

Lactation Safety Information

Minimal absorption from the infant's GI tract
No published evidence of safety
Small amounts in breast milk
24th September 2020

New Medicines

Promixin · Non-cystic fibrosis (CF)-related bronchiectasis - first-line in patients colonised with Pseudomonas aeruginosa

Information

Promixin
Licence extension / variation
Zambon
Zambon

Development and Regulatory status

Phase III Clinical Trials
Phase III Clinical Trials
Phase III Clinical Trials

Category

The pentasodium salt derivative of colistin, a polypeptide antibiotic produced by Bacillus polymyxa var. colistinus
A large study across 640 general practices in the UK found that prevalence in 2011 in men was 227 per 100,000, and 309 per 100,000 in women. It is estimated that around 1,000 people die each year from bronchiectasis in England and Wales. Chronic colonisation by P. aeruginosa, severe exacerbations, and systemic inflammation (raised C-reactive protein) are associated with disease progression in non-cystic fibrosis bronchiectasis. 10% of adults die within 5-8 years of diagnosis [1].
Non-cystic fibrosis (CF)-related bronchiectasis - first-line in patients colonised with Pseudomonas aeruginosa
Inhalation