Collagenase clostridium histolyticum

Articles · Refrigerated Storage · Lactation Safety Information · New Medicines ·
18766111000001107

Articles

Refrigerated Storage

Xiapex · Swedish orphan Biovitrim

Swedish orphan Biovitrim
Xiapex
0.9 mg powder and solvent for solution for injection

Contact Swedish Orphan Biovitrim in all cases where deviation from the recommended storage conditions has occurred. Refer to the current BNF for company contact details.

29th October 2018
London MI Service

Lactation Safety Information

No published evidence of safety
Negligible levels anticipated in milk due to the drug’s properties
17th September 2020

New Medicines

Xiapex (EU), Xiaflex · Frozen shoulder syndrome

Information

Xiapex (EU), Xiaflex
Licence extension / variation
Endo Pharmaceuticals Solutions
Endo Pharmaceuticals Solutions

Development and Regulatory status

None
None
None
Jan 16: Frozen shoulder is not listed as an area of interest on Endo website. PII studies completed in 2013/14 and no further development noted. Assume development has been discontinued [5].

Category

Proteolytic enzymes derived from the fermentation of Clostridium histolyticum and have the ability to break down collagen
Frozen Shoulder syndrome (idiopathic adhesive capsulitis) is a common, prolonged, and painful disorder of diminished shoulder motion. The full duration of the frozen stage of disease can last from 1 to 3.5 years with a mean of 30 months. Increased capsular collagen thickening and subsequent capsular contraction in the glenohumeral joint is thought to cause restriction in both active and passive range of motion in the shoulder. [1]
Frozen shoulder syndrome
Intralesional