Defibrotide

Published

dm+d

441573002

New Medicines

Defitelio Veno-occlusive disorders - prevention in adults and children [1]

Information

Defitelio
Licence extension / variation
Jazz Pharmaceuticals
Jazz Pharmaceuticals

Development and Regulatory status

Phase III Clinical Trials
Phase III Clinical Trials
Phase III Clinical Trials
Yes
Yes

Category

Cytokine modulator that enhances and suppresses factors involved in fibrinolysis and coagulation, respectively, including enhancing the action of plasmin and the anticoagulant effect of heparin
Prevalence is 1 to 5 per 10,000 people. In developed countries, hepatic veno-occlusive disease is mainly associated with the conditioning regimen for hematopoietic stem cell transplantation, with 10 to 60% of transplant patients (depending on the conditioning regimen protocol used) developing hepatic VOD. Hepatic VOD may also occur after chemotherapy or radiation therapy [1].
Veno-occlusive disorders - prevention in adults and children [1]
Intravenous infusion