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Safety in Lactation: Drugs for rectal and anal disorders

21 October 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Rectal glyceryl nitrate and diltiazem (unlicensed)…

Safety in Lactation: Drugs for hypertension

23 September 2020Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance. Many of the drugs covered by…

What are the reported incidences of ankle oedema with different calcium channel blockers?

1 June 2020The potential to cause ankle oedema appears to exist for all calcium channel blocking agents, and is caused by increasing capillary pressure leading to leakage…

How should ankle oedema caused by calcium channel blockers be treated?

1 June 2020Ankle oedema is a common, often troublesome adverse effect for patients who are receiving calcium channel blocker (CCB) therapy, and may affect compliance. It is…
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Refrigerated Storage

AnotopCPM Germany

CPM Germany
Anotop
Cream 2%

In the event of an inadvertent temperature excursion the following data may be used:
Anotop cream can be stored between 8 to 25°C when in use for up to 4 weeks.

Reduce expiry date to 4 weeks. The new expiry date should not exceed the labelled shelf life of the product.
Yes
12 October 2021
London MI Service

Medicine Compliance Aid Stability

TildiemSanofi

Sanofi
Tildiem
Tablets m/r 60mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Adizem SRNapp Pharmaceuticals Ltd

Napp Pharmaceuticals Ltd
Adizem SR
Capsules m/r 90mg, 120mg, 180mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Adizem SRNapp Pharmaceuticals Ltd

Napp Pharmaceuticals Ltd
Adizem SR
Tablets m/r 120mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Adizem XLNapp Pharmaceuticals Ltd

Napp Pharmaceuticals Ltd
Adizem XL
Capsules m/r 120mg, 180mg, 240mg, 300mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Angitil SRChiesi Ltd

Chiesi Ltd
Angitil SR
Capsules m/r 90mg, 120mg, 180mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Angitil XLChiesi Ltd

Chiesi Ltd
Angitil XL
Capsules m/r 240mg, 300mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Dilzem XLCephalon UK Ltd

Cephalon UK Ltd
Dilzem XL
Capsules m/r 120mg, 180mg, 240mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

SlozemMerck Serono

Merck Serono
Slozem
Capsules m/r 120mg, 180mg, 240mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Tildiem LASanofi

Sanofi
Tildiem LA
Capsules m/r 200mg, 300mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Tildiem RetardSanofi

Sanofi
Tildiem Retard
Tablets m/r 90mg, 120mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Viazem XLGenus Pharmaceuticals

Genus Pharmaceuticals
Viazem XL
Capsules m/r 120mg, 180mg, 240mg, 300mg, 360mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Calcicard CRIvax Pharmaceuticals

Ivax Pharmaceuticals
Calcicard CR
Tablets m/r 90mg, 120mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

ZemtardGalen Ltd

Galen Ltd
Zemtard
Capsules m/r 120mg, 180mg, 240mg, 300mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Dilcardia SRGenerics UK Ltd

Generics UK Ltd
Dilcardia SR
Capsules m/r 60mg, 90mg, 120mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Dilzem SRCephalon UK Ltd

Cephalon UK Ltd
Dilzem SR
Capsules m/r 60mg, 90mg
A3 · Amber 3No stability data is available. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation.
Airtight container
Protect from light
Protect from moisture
Should be stored in airtight, light-resistant containers. Excessive humidity should be avoided.
9 November 2015

Lactation Safety Information

Oral

Oral
Nifedipine; Verapamil
Very limited published evidence of safety
Small amounts in breast milk
Monitor infant for adverse effects
16 January 2017

Rectal

Rectal
Glyceryl trinitrate - rectal
Unlicensed in the UK
Low levels anticipated in milk due to the drug’s properties
No published evidence of safety
11 July 2016